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Drug Name ARQ761
Trade Name
Synonyms beta-lapachone|ARQ-761
Drug Descriptions

ARQ761 (beta-lapachone) is metabolized intracellularly by NQO1, generating reactive oxygen species, which leads to DNA damage and PARP1 hyperactivation and potentially results in increased death of NQO1-expressing tumor cells (PMID: 26602448, PMID: 31858276, PMID: 30617135).

DrugClasses
CAS Registry Number NA
NCIT ID C99146

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Therapy Name Drugs Efficacy Evidence Clinical Trials
ARQ761 ARQ761 0 0
ARQ761 + Telaglenastat ARQ761 Telaglenastat 0 0


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