Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name ARS-853
Trade Name
Drug Descriptions

ARS-853 selectively inhibits KRAS G12C, resulting in a decrease in activated KRAS G12C and potentially leading to reduced growth of KRAS G12C-expressing tumor cells (PMID: 26739882, PMID: 32101243).

DrugClasses KRAS G12C inhibitor 27
CAS Registry Number 1629268-00-3


  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"


  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
ARS-853 ARS-853 0 0
ARS-853 + BAY-293 ARS-853 BAY-293 0 0

Additional content available in CKB BOOST