Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name CPI-444
Trade Name
Synonyms Ciforadenant|V81444|CPI 444|CPI444
Drug Descriptions

Ciforadenant (CPI-444) binds to and inhibits A2A (ADORA2A) on immune cells, which may increase anti-tumor immune response and inhibit tumor growth by blocking binding of the immunosuppressive metabolite, adenosine (PMID: 29923026, PMID: 30131376).

DrugClasses Adenosine Targeting 19
CAS Registry Number 1202402-40-1
NCIT ID C125659


  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"


  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + CPI-444 Atezolizumab CPI-444 0 2
CPI-006 + CPI-444 CPI-006 CPI-444 0 1
CPI-444 CPI-444 0 2
CPI-444 + Daratumumab CPI-444 Daratumumab 0 1

Additional content available in CKB BOOST