Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name TVB-2640
Trade Name
Synonyms TVB2640|TVB 2640
Drug Descriptions

TVB-2640 is a fatty acid synthase (FASN) inhibitor that inhibits lipid metabolism in tumor cells (PMID: 26519059, PMID: 31630414).

DrugClasses FASN Inhibitor 5
CAS Registry Number 1399177-37-7
NCIT ID C118285


  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"


  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Anastrozole + Trastuzumab + TVB-2640 Anastrozole TVB-2640 Trastuzumab 0 1
Bevacizumab + TVB-2640 Bevacizumab TVB-2640 0 1
Exemestane + Trastuzumab + TVB-2640 Exemestane TVB-2640 Trastuzumab 0 1
Fulvestrant + Trastuzumab + TVB-2640 Fulvestrant TVB-2640 Trastuzumab 0 1
Paclitaxel + Trastuzumab + TVB-2640 Paclitaxel TVB-2640 Trastuzumab 0 1
Paclitaxel + TVB-2640 Paclitaxel TVB-2640 0 0
TVB-2640 TVB-2640 0 3

Additional content available in CKB BOOST