Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Xevinapant
Trade Name
Synonyms AT-406|SM-406|Debio1143|Debio-1143|Debio 1143
Drug Descriptions

Xevinapant (debio 1143) is a SMAC mimetic, which antagonizes Inhibitor of Apoptosis Protein (IAP) family proteins, resulting in increased tumor cell apoptosis, decreased tumor growth (PMID: 21443232), and may reverse immunosuppression (PMID: 30352911, PMID: 32816847, PMID: 32758455).

DrugClasses SMAC Mimetic 8
CAS Registry Number 1071992-99-8
NCIT ID C90574


  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"


  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Avelumab + Xevinapant Avelumab Xevinapant 0 1
Cisplatin + Xevinapant Cisplatin Xevinapant 0 1
Cytarabine + Daunorubicin + Xevinapant Cytarabine Daunorubicin Xevinapant 0 0
Nivolumab + Xevinapant Nivolumab Xevinapant 0 1
Pembrolizumab + Xevinapant Pembrolizumab Xevinapant 0 1
Xevinapant Xevinapant 0 1

Additional content available in CKB BOOST