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Drug Name Xevinapant
Trade Name
Synonyms AT-406|SM-406|Debio1143|Debio-1143|Debio 1143
Drug Descriptions

Xevinapant (debio 1143) is a SMAC mimetic, which antagonizes Inhibitor of Apoptosis Protein (IAP) family proteins, resulting in increased tumor cell apoptosis, decreased tumor growth (PMID: 21443232), and may reverse immunosuppression (PMID: 30352911, PMID: 32758455).

DrugClasses SMAC Mimetic 8
CAS Registry Number 1071992-99-8
NCIT ID C90574

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Avelumab + Xevinapant Avelumab Xevinapant 0 1
Carboplatin + Paclitaxel + Xevinapant Carboplatin Paclitaxel Xevinapant 0 1
Cetuximab + Xevinapant Cetuximab Xevinapant 0 1
Cisplatin + Xevinapant Cisplatin Xevinapant 0 3
Cytarabine + Daunorubicin + Xevinapant Cytarabine Daunorubicin Xevinapant 0 0
Nivolumab + Xevinapant Nivolumab Xevinapant 0 1
Pembrolizumab + Xevinapant Pembrolizumab Xevinapant 0 1
Xevinapant Xevinapant 0 4


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