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Drug Name Plinabulin
Trade Name
Synonyms NPI-2358
Drug Descriptions

Plinabulin (NPI-2358) is a diketopiperazine derivative that disrupts microtubule organization, leading to cell cycle arrest in tumor cells and collapse of tumor vasculature (PMID: 16317287, PMID: 31811421).

DrugClasses Antimicrotubule Agent 14
CAS Registry Number 714272-27-2
NCIT ID C62444


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + Avelumab + Durvalumab + Nivolumab + Pembrolizumab + Plinabulin Atezolizumab Avelumab Durvalumab Nivolumab Pembrolizumab Plinabulin 0 1
Docetaxel + Plinabulin Docetaxel Plinabulin 0 1
Ipilimumab + Nivolumab + Plinabulin Ipilimumab Nivolumab Plinabulin 0 1
Nivolumab + Plinabulin Nivolumab Plinabulin 0 2
Plinabulin Plinabulin 0 2

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