Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name INCB053914
Trade Name
Synonyms INCB53914
Drug Descriptions

INCB053914 is an ATP-competitive small molecule inhibitor of PIM kinases 1, 2, and 3, which may inhibit cell proliferation by blocking the phosphorylation of downstream targets (PMID: 29927999, PMID: 31725895).

DrugClasses PIM Inhibitor (Pan) 9
CAS Registry Number 2088852-47-3
NCIT ID C124226

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Cytarabine + INCB053914 Cytarabine INCB053914 0 0
INCB053914 INCB053914 3 1
INCB053914 + INCB054329 INCB053914 INCB054329 0 0
INCB053914 + INCB057643 INCB053914 INCB057643 0 0
INCB053914 + Itacitinib INCB053914 Itacitinib 0 0
INCB053914 + Parsaclisib INCB053914 Parsaclisib 0 1


Additional content available in CKB BOOST