Drug Detail


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Drug Name INCB053914
Trade Name
Synonyms INCB53914
Drug Descriptions

INCB053914 is an ATP-competitive small molecule inhibitor of PIM kinases 1, 2, and 3, which may inhibit cell proliferation by blocking the phosphorylation of downstream targets (PMID: 29927999, PMID: 31725895).

DrugClasses PIM Inhibitor (Pan) 9
CAS Registry Number 2088852-47-3
NCIT ID C124226


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cytarabine + INCB053914 Cytarabine INCB053914 0 0
INCB053914 INCB053914 3 1
INCB053914 + Itacitinib INCB053914 Itacitinib 0 0
INCB053914 + Parsaclisib INCB053914 Parsaclisib 0 1

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