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Drug Name Pepinemab
Trade Name
Synonyms VX15/2503
Drug Descriptions

Pepinemab (VX15/2503) is a monoclonal antibody that binds to semaphorin 4D (SEMA4D) and blocks plexin-B1 binding, leading to anti-tumor and immune regulatory activity (PMID: 26446947, PMID: 28642891).

DrugClasses
CAS Registry Number 2097151-87-4
NCIT ID C96222

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Avelumab + Pepinemab Avelumab Pepinemab 0 1
Ipilimumab + Nivolumab + Pepinemab Ipilimumab Nivolumab Pepinemab 0 1
Ipilimumab + Pepinemab Ipilimumab Pepinemab 0 4
Nivolumab + Pepinemab Nivolumab Pepinemab 0 4
Pembrolizumab + Pepinemab Pembrolizumab Pepinemab 0 1
Pepinemab Pepinemab 0 4


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