Drug Detail


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Drug Name APX005M
Trade Name
Synonyms EPI-0050|APX-005M|APX 005M|Sotigalimab
Drug Descriptions

APX005M (Sotigalimab) is a monoclonal antibody to TNFRSF5 (CD40), which mimics the binding of the ligand, CD40LG (CD40L), to stimulate proliferation of T-cells and enhance an anti-tumor response (PMID: 31275618).

DrugClasses CD40 Antibody 14
CAS Registry Number 2305607-45-6
NCIT ID C123734


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Therapy Name Drugs Efficacy Evidence Clinical Trials
AB154 + APX005M + Zimberelimab AB154 APX005M Zimberelimab 0 1
APX005M APX005M 0 4
APX005M + Cabiralizumab APX005M Cabiralizumab 0 1
APX005M + Cabiralizumab + Nivolumab APX005M Cabiralizumab Nivolumab 0 1
APX005M + Carboplatin + Paclitaxel APX005M Carboplatin Paclitaxel 0 1
APX005M + Doxorubicin + Olaratumab APX005M Doxorubicin Olaratumab 0 1
APX005M + Fluorouracil + Leucovorin + Oxaliplatin APX005M Fluorouracil Leucovorin Oxaliplatin 0 0
APX005M + Gemcitabine + Nab-paclitaxel APX005M Gemcitabine Nab-paclitaxel 0 1
APX005M + Gemcitabine + Nab-paclitaxel + Nivolumab APX005M Gemcitabine Nab-paclitaxel Nivolumab 0 1
APX005M + Ipilimumab + Nivolumab APX005M Ipilimumab Nivolumab 0 1
APX005M + NEO-PV-01 APX005M NEO-PV-01 0 0
APX005M + NEO-PV-01 + Nivolumab + Poly ICLC APX005M NEO-PV-01 Nivolumab Poly ICLC 0 1
APX005M + Nivolumab APX005M Nivolumab 0 2
APX005M + Pembrolizumab APX005M Pembrolizumab 0 1

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