Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name APX005M
Trade Name
Synonyms EPI-0050|APX-005M|APX 005M|Sotigalimab
Drug Descriptions

APX005M (Sotigalimab) is a monoclonal antibody to TNFRSF5 (CD40), which mimics the binding of the ligand, CD40LG (CD40L), to stimulate proliferation of T-cells and enhance an anti-tumor response (PMID: 31275618).

DrugClasses CD40 Antibody 14
CAS Registry Number 2305607-45-6
NCIT ID C123734

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
AB154 + APX005M + Zimberelimab AB154 APX005M Zimberelimab 0 1
APX005M APX005M 0 4
APX005M + Cabiralizumab APX005M Cabiralizumab 0 1
APX005M + Cabiralizumab + Nivolumab APX005M Cabiralizumab Nivolumab 0 1
APX005M + Carboplatin + Paclitaxel APX005M Carboplatin Paclitaxel 0 1
APX005M + Doxorubicin + Olaratumab APX005M Doxorubicin Olaratumab 0 1
APX005M + Fluorouracil + Leucovorin + Oxaliplatin APX005M Fluorouracil Leucovorin Oxaliplatin 0 0
APX005M + Gemcitabine + Nab-paclitaxel APX005M Gemcitabine Nab-paclitaxel 0 1
APX005M + Gemcitabine + Nab-paclitaxel + Nivolumab APX005M Gemcitabine Nab-paclitaxel Nivolumab 0 1
APX005M + Ipilimumab + Nivolumab APX005M Ipilimumab Nivolumab 0 1
APX005M + NEO-PV-01 APX005M NEO-PV-01 0 0
APX005M + NEO-PV-01 + Nivolumab + Poly ICLC APX005M NEO-PV-01 Nivolumab Poly ICLC 0 1
APX005M + Nivolumab APX005M Nivolumab 0 2
APX005M + Pembrolizumab APX005M Pembrolizumab 0 1


Additional content available in CKB BOOST