Drug Detail


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Drug Name Sotigalimab
Trade Name
Synonyms APX005M|EPI-0050|APX-005M|APX 005M
Drug Descriptions

Sotigalimab (APX005M) is a monoclonal antibody to TNFRSF5 (CD40), which mimics the binding of the ligand, CD40LG (CD40L), to stimulate proliferation of T-cells and enhance an anti-tumor response (PMID: 31275618).

DrugClasses CD40 Antibody 14
CAS Registry Number 2305607-45-6
NCIT ID C123734


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Therapy Name Drugs Efficacy Evidence Clinical Trials
AB154 + Sotigalimab + Zimberelimab AB154 Sotigalimab Zimberelimab 0 1
Cabiralizumab + Nivolumab + Sotigalimab Cabiralizumab Nivolumab Sotigalimab 0 1
Cabiralizumab + Sotigalimab Cabiralizumab Sotigalimab 0 1
Carboplatin + Paclitaxel + Sotigalimab Carboplatin Paclitaxel Sotigalimab 0 1
Doxorubicin + Olaratumab + Sotigalimab Doxorubicin Olaratumab Sotigalimab 0 1
Fluorouracil + Leucovorin + Oxaliplatin + Sotigalimab Fluorouracil Leucovorin Oxaliplatin Sotigalimab 0 0
Gemcitabine + Nab-paclitaxel + Nivolumab + Sotigalimab Gemcitabine Nab-paclitaxel Nivolumab Sotigalimab 0 1
Gemcitabine + Nab-paclitaxel + Sotigalimab Gemcitabine Nab-paclitaxel Sotigalimab 0 1
Ipilimumab + Nivolumab + Sotigalimab Ipilimumab Nivolumab Sotigalimab 0 1
NEO-PV-01 + Nivolumab + Poly ICLC + Sotigalimab NEO-PV-01 Nivolumab Poly ICLC Sotigalimab 0 1
NEO-PV-01 + Sotigalimab NEO-PV-01 Sotigalimab 0 0
Nivolumab + Sotigalimab Nivolumab Sotigalimab 0 2
Pembrolizumab + Sotigalimab Pembrolizumab Sotigalimab 0 1
Sotigalimab Sotigalimab 0 4

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