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CGP57380 inhibits MAPK-interacting protein kinase (MNK) 1 and 2, and may have additional activity against other protein kinases, leading to decreased phosphorylation of eIF4E and potentially resulting in decreased tumor cell growth and migration (PMID: 17850214, PMID: 21406405, PMID: 26609108, PMID: 30297804).
|DrugClasses||MNK1/2 Inhibitor 3|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|