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Drug Name SN-38
Trade Name
Synonyms SN 38|SN38
Drug Descriptions

SN-38 is a metabolite of the topoisomerase inhibitor irinotecan, which causes cell cycle arrest and apoptotic induction, potentially leading to tumor growth inhibition (PMID: 21609311).

DrugClasses TOPO Inhibitor (Pan) 3
CAS Registry Number 86639-52-3
NCIT ID C61618


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Therapy Name Drugs Efficacy Evidence Clinical Trials
CHIR-124 + SN-38 CHIR-124 SN-38 2 0
Niraparib + SN-38 Niraparib SN-38 0 0
Olaparib + SN-38 Olaparib SN-38 0 0
Olaparib + SN-38 + Temozolomide Olaparib SN-38 Temozolomide 0 0
SN-38 SN-38 0 0
SN-38 + Talazoparib SN-38 Talazoparib 0 0
SN-38 + Veliparib SN-38 Veliparib 0 0
SN-38 + VX-803 SN-38 VX-803 0 0

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