Drug Detail


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Drug Name BGB-283
Trade Name
Synonyms Lifirafenib
Drug Descriptions

Lifirafenib (BGB-283) is a dual RAF kinase and EGFR inhibitor, which may lead to decreased tumor cell proliferation and reduced growth of tumors with activation of BRAF and/or EGFR (PMID: 26208524, PMID: 32182156).

DrugClasses BRAF Inhibitor 21 EGFR Inhibitor (Pan) 55
CAS Registry Number 1446090-79-4
NCIT ID C124995


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Therapy Name Drugs Efficacy Evidence Clinical Trials
BGB-283 BGB-283 10 1
BGB-283 + Cetuximab BGB-283 Cetuximab 1 0
BGB-283 + MK-8353 BGB-283 MK-8353 2 0
BGB-283 + PD-0325901 BGB-283 PD-0325901 1 1
BGB-283 + Pimasertib BGB-283 Pimasertib 1 0
BGB-283 + SCH772984 BGB-283 SCH772984 3 0
BGB-283 + Selumetinib BGB-283 Selumetinib 0 0
BGB-283 + Trametinib BGB-283 Trametinib 4 0
BGB-283 + Ulixertinib BGB-283 Ulixertinib 2 0
BGB-283 + Vemurafenib BGB-283 Vemurafenib 2 0

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