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Drug Name Enfortumab vedotin-ejfv
Trade Name Padcev
Synonyms AGS-22ME
Drug Descriptions

Padcev (enfortumab vedotin-ejfv) is an antibody drug conjugate that fuses together a human antibody against NECTIN4 and monomethyl auristatin E, which may result in inhibition of tumor growth and tumor regression (PMID: 27013195). Padcev (enfortumab vedotin-ejfv) is FDA approved for use in patients with locally advanced or metastatic urothelial cancer who have previously received a PD-1 or PD-L1 inhibitor, and a platinum-containing chemotherapy, or who are ineligible for cisplatin-containing chemotherapy and have previously received one or more prior lines of therapy (FDA.gov).

DrugClasses
CAS Registry Number 1346452-25-2
NCIT ID C114500

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + Enfortumab vedotin-ejfv Atezolizumab Enfortumab vedotin-ejfv 0 1
Atezolizumab + Enfortumab vedotin-ejfv + Pembrolizumab Atezolizumab Enfortumab vedotin-ejfv Pembrolizumab 0 1
Cabozantinib + Enfortumab vedotin-ejfv Cabozantinib Enfortumab vedotin-ejfv 0 1
Carboplatin + Enfortumab vedotin-ejfv + Pembrolizumab Carboplatin Enfortumab vedotin-ejfv Pembrolizumab 0 1
Cisplatin + Enfortumab vedotin-ejfv + Pembrolizumab Cisplatin Enfortumab vedotin-ejfv Pembrolizumab 0 1
Durvalumab + Enfortumab vedotin-ejfv Durvalumab Enfortumab vedotin-ejfv 0 0
Durvalumab + Enfortumab vedotin-ejfv + Tremelimumab Durvalumab Enfortumab vedotin-ejfv Tremelimumab 0 1
Enfortumab vedotin-ejfv Enfortumab vedotin-ejfv 0 4
Enfortumab vedotin-ejfv + Erdafitinib Enfortumab vedotin-ejfv Erdafitinib 0 1
Enfortumab vedotin-ejfv + MGCD516 Enfortumab vedotin-ejfv MGCD516 0 1
Enfortumab vedotin-ejfv + Pembrolizumab Enfortumab vedotin-ejfv Pembrolizumab 0 2


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