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Drug Name Cirmtuzumab
Trade Name
Synonyms UC-961
Drug Descriptions

Cirmtuzumab (UC-961) is a monoclonal antibody that binds to human receptor tyrosine kinase-like orphan receptor 1 (ROR1) and blocks ROR1 signaling, leading to growth inhibition in tumor cells (PMID: 26297272, PMID: 29859176, PMID: 32090643).

DrugClasses ROR1 Antibody 7
CAS Registry Number 1643432-38-5
NCIT ID C118284

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cirmtuzumab Cirmtuzumab 0 3
Cirmtuzumab + Docetaxel Cirmtuzumab Docetaxel 0 1
Cirmtuzumab + Ibrutinib Cirmtuzumab Ibrutinib 0 1
Cirmtuzumab + Paclitaxel Cirmtuzumab Paclitaxel 0 1
Cirmtuzumab + Venetoclax Cirmtuzumab Venetoclax 0 1


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