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JCAR014 is composed of autologous CD8 and CD4+ memory T-cells expressing a chimeric antigen receptor (CAR) comprised of a CD19 scFv-4-1BB-CD3zeta fusion protein and truncated EGFR, which may stimulate anti-tumor immunity (NCI Drug Dictionary).
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|Cyclophosphamide + Durvalumab + JCAR014||Cyclophosphamide Durvalumab JCAR014||0||1|