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Drug Name LXH 254
Trade Name
Synonyms LXH254|LXH-254|Naporafenib
Drug Descriptions

LXH 254 is a RAF inhibitor that selectively inhibits monomeric and dimerized BRAF and CRAF, which may lead to anti-tumor activity in RAF-mutant tumors and better tolerability (AACR Annual Meeting 2019, Abstract LB-114, PMID: 31059256).

DrugClasses BRAF Inhibitor 25 CRAF Inhibitor 12
CAS Registry Number 1800398-38-2
NCIT ID C125003

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Dabrafenib + LTT462 + LXH 254 Dabrafenib LTT462 LXH 254 0 1
Dabrafenib + LXH 254 + Trametinib Dabrafenib LXH 254 Trametinib 2 0
LTT462 + LXH 254 LTT462 LXH 254 4 2
LXH 254 LXH 254 18 1
LXH 254 + Nazartinib LXH 254 Nazartinib 0 1
LXH 254 + Ribociclib LXH 254 Ribociclib 0 1
LXH 254 + SHP099 LXH 254 SHP099 0 0
LXH 254 + Spartalizumab LXH 254 Spartalizumab 0 1
LXH 254 + Trametinib LXH 254 Trametinib 5 3


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