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Drug Name Amivantamab-vmjw
Trade Name Rybrevant
Synonyms JNJ-61186372
Drug Descriptions

Rybrevant (amivantamab-vmjw) is a bi-specific antibody that targets EGFR and MET, resulting in inhibition of downstream signaling and potentially leading to decreased growth of EGFR and/or MET-expressing tumors (PMID: 27216193, PMID: 32414908). Rybrevant (amivantamab-vmjw) is FDA approved for use in patients with locally advanced or metastatic non-small cell lung cancer harboring EGFR exon 20 insertion mutations, whose disease has progressed on or after platinum-based chemotherapy (FDA.gov).

DrugClasses EGFR Antibody 40 MET Antibody 22
CAS Registry Number 2171511-58-1
NCIT ID C124993

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Amivantamab-vmjw Amivantamab-vmjw 0 6
Amivantamab-vmjw + Capmatinib Amivantamab-vmjw Capmatinib 0 1
Amivantamab-vmjw + Carboplatin + Lazertinib + Pemetrexed Disodium Amivantamab-vmjw Carboplatin Lazertinib Pemetrexed Disodium 0 2
Amivantamab-vmjw + Carboplatin + Pemetrexed Disodium Amivantamab-vmjw Carboplatin Pemetrexed Disodium 0 4
Amivantamab-vmjw + Fluorouracil + Irinotecan + Leucovorin Amivantamab-vmjw Fluorouracil Irinotecan Leucovorin 0 1
Amivantamab-vmjw + Fluorouracil + Leucovorin + Oxaliplatin Amivantamab-vmjw Fluorouracil Leucovorin Oxaliplatin 0 1
Amivantamab-vmjw + Lazertinib Amivantamab-vmjw Lazertinib 0 7
Amivantamab-vmjw + Lazertinib + rHuPH20 Amivantamab-vmjw Lazertinib rHuPH20 0 1
Amivantamab-vmjw + Osimertinib Amivantamab-vmjw Osimertinib 0 0
Amivantamab-vmjw + rHuPH20 Amivantamab-vmjw rHuPH20 0 1


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