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| Drug Name | Amivantamab-vmjw |
| Trade Name | Rybrevant |
| Synonyms | JNJ-61186372 |
| Drug Descriptions |
Rybrevant (amivantamab-vmjw) is a bi-specific antibody that targets EGFR and MET, resulting in inhibition of downstream signaling and potentially leading to decreased growth of EGFR and/or MET-expressing tumors (PMID: 27216193, PMID: 32414908). Rybrevant (amivantamab-vmjw) is FDA approved for use in patients with locally advanced or metastatic non-small cell lung cancer harboring EGFR exon 20 insertion mutations, whose disease has progressed on or after platinum-based chemotherapy (FDA.gov). |
| DrugClasses | EGFR Antibody 52 MET Antibody 26 |
| CAS Registry Number | 2171511-58-1 |
| NCIT ID | C124993 |
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