Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name amivantamab-vmjw
Trade Name Rybrevant
Synonyms JNJ-61186372
Drug Descriptions

Rybrevant (amivantamab-vmjw) is a bi-specific antibody that targets EGFR and MET, resulting in inhibition of downstream signaling and potentially leading to decreased growth of EGFR and/or MET-expressing tumors (PMID: 27216193, PMID: 32414908). Rybrevant (amivantamab-vmjw) is FDA approved for use in patients with locally advanced or metastatic non-small cell lung cancer harboring EGFR exon 20 insertion mutations, whose disease has progressed on or after platinum-based chemotherapy (FDA.gov).

DrugClasses EGFR Antibody 31 MET Antibody 18
CAS Registry Number 2171511-58-1
NCIT ID C124993


  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"


  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
amivantamab-vmjw amivantamab-vmjw 0 1
amivantamab-vmjw + Carboplatin + Lazertinib + Pemetrexed Disodium Carboplatin Lazertinib Pemetrexed Disodium amivantamab-vmjw 0 1
amivantamab-vmjw + Carboplatin + Pemetrexed Disodium Carboplatin Pemetrexed Disodium amivantamab-vmjw 0 3
amivantamab-vmjw + Lazertinib Lazertinib amivantamab-vmjw 0 4
amivantamab-vmjw + Osimertinib Osimertinib amivantamab-vmjw 0 0

Additional content available in CKB BOOST