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Drug Name amivantamab-vmjw
Trade Name Rybrevant
Synonyms JNJ-61186372
Drug Descriptions

Rybrevant (amivantamab-vmjw) is a bi-specific antibody that targets EGFR and MET, resulting in inhibition of downstream signaling and potentially leading to decreased growth of EGFR and/or MET-expressing tumors (PMID: 27216193, PMID: 32414908). Rybrevant (amivantamab-vmjw) is FDA approved for use in patients with locally advanced or metastatic non-small cell lung cancer harboring EGFR exon 20 insertion mutations, whose disease has progressed on or after platinum-based chemotherapy (FDA.gov).

DrugClasses EGFR Antibody 31 MET Antibody 18
CAS Registry Number 2171511-58-1
NCIT ID C124993

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Therapy Name Drugs Efficacy Evidence Clinical Trials
amivantamab-vmjw amivantamab-vmjw 0 1
amivantamab-vmjw + Carboplatin + Lazertinib + Pemetrexed Disodium Carboplatin Lazertinib Pemetrexed Disodium amivantamab-vmjw 0 1
amivantamab-vmjw + Carboplatin + Pemetrexed Disodium Carboplatin Pemetrexed Disodium amivantamab-vmjw 0 3
amivantamab-vmjw + Lazertinib Lazertinib amivantamab-vmjw 0 4
amivantamab-vmjw + Osimertinib Osimertinib amivantamab-vmjw 0 0


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