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EAI045 is a 4th generation, allosteric, non-ATP competitive inhibitor of epidermal growth factor receptor (EGFR) with selective activity against EGFR L858R/T790M and C797S, which when combined with anti-EGFR antibodies may lead to growth inhibition in tumors harboring EGFR T790M or C797S (PMID: 27251290, PMID: 27840244, PMID: 32666476).
|DrugClasses||EGFR Inhibitor 4th gen 9|
|CAS Registry Number||1942114-09-1|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|Cetuximab + EAI045||Cetuximab EAI045||0||0|
|EAI045 + Osimertinib||EAI045 Osimertinib||0||0|