Drug Detail


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Drug Name EAI045
Trade Name
Synonyms EAI-045|EAI 045
Drug Descriptions

EAI045 is a 4th generation, allosteric, non-ATP competitive inhibitor of epidermal growth factor receptor (EGFR) with selective activity against EGFR L858R/T790M and C797S, which when combined with anti-EGFR antibodies may lead to growth inhibition in tumors harboring EGFR T790M or C797S (PMID: 27251290, PMID: 27840244, PMID: 32666476).

DrugClasses EGFR Inhibitor 4th gen 13
CAS Registry Number 1942114-09-1


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cetuximab + EAI045 Cetuximab EAI045 0 0
EAI045 EAI045 0 0
EAI045 + Osimertinib EAI045 Osimertinib 0 0

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