Drug Detail


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Drug Name Trastuzumab Duocarmazine
Trade Name
Synonyms SYD985|SYD-985|Trastuzumab vc-seco-DUBA|SYD 985|T-Duo
Drug Descriptions

Trastuzumab Duocarmazine (SYD985) is an antibody-drug conjugate (ADC) consisting of the Erbb2 (Her2)-targeting antibody trastuzumab bound to a derivative of the cytotoxic drug duocarmycin, which results in increased death of Erbb2 (Her2)-expressing tumor cells (PMID: 27256376).

DrugClasses HER2 (ERBB2) Antibody 64 HER2 (ERBB2) Antibody-Drug Conjugate 24
CAS Registry Number 1642152-40-6
NCIT ID C118674


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Niraparib + Trastuzumab Duocarmazine Niraparib Trastuzumab Duocarmazine 0 1
Paclitaxel + Trastuzumab Duocarmazine Paclitaxel Trastuzumab Duocarmazine 0 1
Trastuzumab Duocarmazine Trastuzumab Duocarmazine 0 3

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