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CBP501 is a peptide drug that inhibits the activity of several kinases responsible for phosphorylation of CDC25C, including MAPKAP-K2, C-Tak1, and CHK1, resulting in disruption of the G2 checkpoint and potentially leading to cell-cycle arrest and increased tumor cell death (PMID: 17237275, PMID: 29088764).
|DrugClasses||CHK1 Inhibitor 14|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|Bleomycin + CBP501||Bleomycin CBP501||2||0|
|CBP501 + Cisplatin||CBP501 Cisplatin||3||0|
|CBP501 + Cisplatin + Nivolumab||CBP501 Cisplatin Nivolumab||1||1|