Drug Detail


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Drug Name CBP501
Trade Name
Synonyms CBP-501|CBP 501
Drug Descriptions

CBP501 is a peptide drug that inhibits the activity of several kinases responsible for phosphorylation of CDC25C, including MAPKAP-K2, C-Tak1, and CHK1, resulting in disruption of the G2 checkpoint and potentially leading to cell-cycle arrest and increased tumor cell death (PMID: 17237275, PMID: 29088764).

DrugClasses CHK1 Inhibitor 15
CAS Registry Number 565434-85-7
NCIT ID C71529


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bleomycin + CBP501 Bleomycin CBP501 0 0
CBP501 CBP501 0 0
CBP501 + Cisplatin CBP501 Cisplatin 0 1
CBP501 + Cisplatin + Nivolumab CBP501 Cisplatin Nivolumab 0 2

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