Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Pexmetinib
Trade Name
Synonyms ARRY-614
Drug Descriptions

Pexmetinib (ARRY-614) inhibits Tie2, p38, and the BCR-ABL1 fusion, potentially leading to decreased cell proliferation and inhibition of tumor growth (PMID: 27287719, PMID: 25480830, PMID: 38750137).

DrugClasses BCR-ABL Inhibitor 32
CAS Registry Number 945614-12-0
NCIT ID C85481

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Ipilimumab + Pexmetinib Ipilimumab Pexmetinib 0 1
Nivolumab + Pexmetinib Nivolumab Pexmetinib 0 1
Pexmetinib Pexmetinib 0 0


Additional content available in CKB BOOST