Drug Detail


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Drug Name Pexmetinib
Trade Name
Synonyms ARRY-614
Drug Descriptions

Pexmetinib (ARRY-614) inhibits Tie2, p38, and the BCR-ABL1 fusion, potentially leading to decreased cell proliferation and inhibition of tumor growth (PMID: 27287719, PMID: 25480830, PMID: 38750137).

DrugClasses BCR-ABL Inhibitor 32
CAS Registry Number 945614-12-0
NCIT ID C85481


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Ipilimumab + Pexmetinib Ipilimumab Pexmetinib 0 1
Nivolumab + Pexmetinib Nivolumab Pexmetinib 0 1
Pexmetinib Pexmetinib 0 0

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