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Drug Name PAC-1
Trade Name
Synonyms VO-100
Drug Descriptions

PAC-1 is a small molecule activator of procaspase 3, which occurs via inhibition of zinc ions, resulting in autoactivation and thus, may lead to apoptotis and anti-tumor activity (PMID: 19281821, PMID: 27297867).

DrugClasses
CAS Registry Number 315183-21-2
NCIT ID C120318

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Entrectinib + PAC-1 Entrectinib PAC-1 0 1
PAC-1 PAC-1 0 1
PAC-1 + Temozolomide PAC-1 Temozolomide 0 1
PAC-1 + Trametinib + Vemurafenib PAC-1 Trametinib Vemurafenib 1 0
PAC-1 + Vemurafenib PAC-1 Vemurafenib 1 0


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