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E7107 is a derivative of Pladienolide D, which inhibits assembly of the spliceosome specifically by binding to SF3B1, thereby inhibiting splicing of pre-mRNA and cell-cycle progression (PMID: 27622333).
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|E7107 + GSK3203591||E7107 GSK3203591||1||0|
|E7107 + GSK3203591 + MS023||E7107 GSK3203591 MS023||1||0|
|E7107 + MS023||E7107 MS023||1||0|