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Drug Name Utomilumab
Trade Name
Synonyms PF-05082566|PF05082566
Drug Descriptions

Utomilumab (PF-05082566) is an activating monoclonal antibody that targets and antagonizes CD137 (4-1BB), potentially resulting in increased immune response against tumor cells (PMID: 27369047, PMID: 32144134).

DrugClasses

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Ado-trastuzumab emtansine + Utomilumab Ado-trastuzumab emtansine Utomilumab 0 1
Aldesleukin + Cyclophosphamide + Utomilumab Aldesleukin Cyclophosphamide Utomilumab 0 1
Avelumab + Azacitidine + Utomilumab Avelumab Azacitidine Utomilumab 0 1
Avelumab + Carboplatin + Etoposide + Ifosfamide + Rituximab + Utomilumab Avelumab Carboplatin Etoposide Ifosfamide Rituximab Utomilumab 0 1
Avelumab + Ibrutinib + Rituximab + Utomilumab Avelumab Ibrutinib Rituximab Utomilumab 0 1
Avelumab + PF-04518600 + Utomilumab Avelumab PF-04518600 Utomilumab 0 2
Avelumab + Rituximab + Utomilumab Avelumab Rituximab Utomilumab 0 2
Avelumab + Trastuzumab + Utomilumab Avelumab Trastuzumab Utomilumab 0 1
Avelumab + Trastuzumab + Utomilumab + Vinorelbine Avelumab Trastuzumab Utomilumab Vinorelbine 0 1
Avelumab + Utomilumab Avelumab Utomilumab 0 4
Cetuximab + Irinotecan + Utomilumab Cetuximab Irinotecan Utomilumab 0 1
ISA101b + Utomilumab ISA101b Utomilumab 0 1
KTE-C19 + Utomilumab KTE-C19 Utomilumab 0 1
Mogamulizumab + Utomilumab Mogamulizumab Utomilumab 0 1
Pembrolizumab + Utomilumab Pembrolizumab Utomilumab 1 0
PF-04518600 + Rituximab + Utomilumab PF-04518600 Rituximab Utomilumab 0 1
PF-04518600 + Utomilumab PF-04518600 Utomilumab 0 2
Rituximab + Utomilumab Rituximab Utomilumab 0 1
Trastuzumab + Utomilumab Trastuzumab Utomilumab 0 1
Utomilumab Utomilumab 3 2


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