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Drug Name NHS-IL12
Trade Name
Synonyms M9241|M-9241
Drug Descriptions

NHS-IL12 (M9241) is an immunocytokine composed of IL-12 linked to human tumor necrosis factor targeted IgG1, which may result in enhanced anti-tumor immune response (PMID: 24681847).

CAS Registry Number 1807503-77-0
NCIT ID C97961


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Avelumab + NHS-IL12 Avelumab NHS-IL12 0 1
Bintrafusp alfa + CV301 + NHS-IL12 + Nogapendekin alfa inbakicept Bintrafusp alfa CV301 NHS-IL12 Nogapendekin alfa inbakicept 0 1
Bintrafusp alfa + Degarelix + Docetaxel + NHS-IL12 + Prednisone Bintrafusp alfa Degarelix Docetaxel NHS-IL12 Prednisone 0 1
Bintrafusp alfa + Docetaxel + NHS-IL12 Bintrafusp alfa Docetaxel NHS-IL12 0 1
Bintrafusp alfa + Entinostat + NHS-IL12 Bintrafusp alfa Entinostat NHS-IL12 0 1
Bintrafusp alfa + NHS-IL12 Bintrafusp alfa NHS-IL12 0 4
Bintrafusp alfa + NHS-IL12 + PDS0101 Bintrafusp alfa NHS-IL12 PDS0101 0 1
Degarelix + Docetaxel + NHS-IL12 + Prednisone Degarelix Docetaxel NHS-IL12 Prednisone 0 1
Docetaxel + NHS-IL12 Docetaxel NHS-IL12 0 1
Docetaxel + NHS-IL12 + Prednisone Docetaxel NHS-IL12 Prednisone 0 0
Entinostat + NHS-IL12 Entinostat NHS-IL12 0 1
Enzalutamide + NHS-IL12 Enzalutamide NHS-IL12 0 1
Fluorouracil + Irinotecan + Leucovorin + NHS-IL12 Fluorouracil Irinotecan Leucovorin NHS-IL12 0 1
Fluorouracil + Leucovorin + NHS-IL12 + Oxaliplatin Fluorouracil Leucovorin NHS-IL12 Oxaliplatin 0 1
Irinotecan + Leucovorin + NHS-IL12 Irinotecan Leucovorin NHS-IL12 0 0
NHS-IL12 NHS-IL12 0 3

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