Drug Detail


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Drug Name GDC-0077
Trade Name
Synonyms RO7113755|RG6114|GDC0077|GDC 0077|inavolisib
Drug Descriptions

GDC-0077 inhibits PIK3CA, with selectivity for mutant PIK3CA over wild-type PIK3CA, potentially resulting in increased apoptosis and decreased growth of PIK3CA-mutant tumors (AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 156).

DrugClasses PIK3CA inhibitor 18
CAS Registry Number 2060571-02-8
NCIT ID C132166


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Ado-trastuzumab emtansine + GDC-0077 Ado-trastuzumab emtansine GDC-0077 0 0
Bevacizumab + GDC-0077 Bevacizumab GDC-0077 0 1
Capecitabine + GDC-0077 Capecitabine GDC-0077 0 1
Cetuximab + GDC-0077 Cetuximab GDC-0077 0 1
Fulvestrant + GDC-0077 Fulvestrant GDC-0077 0 1
Fulvestrant + GDC-0077 + Palbociclib Fulvestrant GDC-0077 Palbociclib 0 1
GDC-0077 GDC-0077 8 4
GDC-0077 + Giredestrant GDC-0077 Giredestrant 0 1
GDC-0077 + Lapatinib GDC-0077 Lapatinib 0 0
GDC-0077 + Letrozole GDC-0077 Letrozole 0 1
GDC-0077 + Letrozole + Palbociclib GDC-0077 Letrozole Palbociclib 0 1
GDC-0077 + Pertuzumab + Trastuzumab GDC-0077 Pertuzumab Trastuzumab 0 0

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