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Drug Name Inavolisib
Trade Name
Synonyms GDC-0077|RO7113755|RG6114|GDC0077|GDC 0077
Drug Descriptions

Inavolisib (GDC-0077) inhibits PIK3CA, with selectivity for mutant PIK3CA over wild-type PIK3CA, potentially resulting in increased apoptosis and decreased growth of PIK3CA-mutant tumors (PMID: 36455032).

DrugClasses PIK3CA inhibitor 23
CAS Registry Number 2060571-02-8
NCIT ID C132166

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Ado-trastuzumab emtansine + Inavolisib Ado-trastuzumab emtansine Inavolisib 0 0
Bevacizumab + Inavolisib Bevacizumab Inavolisib 0 1
Capecitabine + Inavolisib Capecitabine Inavolisib 0 1
Cetuximab + Inavolisib Cetuximab Inavolisib 0 1
Fulvestrant + Inavolisib Fulvestrant Inavolisib 0 2
Fulvestrant + Inavolisib + Palbociclib Fulvestrant Inavolisib Palbociclib 0 1
Giredestrant + Inavolisib Giredestrant Inavolisib 0 1
Inavolisib Inavolisib 18 4
Inavolisib + Lapatinib Inavolisib Lapatinib 0 0
Inavolisib + Letrozole Inavolisib Letrozole 0 1
Inavolisib + Letrozole + Palbociclib Inavolisib Letrozole Palbociclib 0 1
Inavolisib + Pertuzumab + Trastuzumab Inavolisib Pertuzumab Trastuzumab 0 0
Inavolisib + Pertuzumab/trastuzumab/hyaluronidase-zzxf Inavolisib Pertuzumab/trastuzumab/hyaluronidase-zzxf 0 1
Inavolisib + Pertuzumab/trastuzumab/hyaluronidase-zzxf + Tamoxifen Inavolisib Pertuzumab/trastuzumab/hyaluronidase-zzxf Tamoxifen 0 1


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