Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name GDC-0077
Trade Name
Synonyms RO7113755|RG6114|GDC0077|GDC 0077|inavolisib
Drug Descriptions

GDC-0077 inhibits PIK3CA, with selectivity for mutant PIK3CA over wild-type PIK3CA, potentially resulting in increased apoptosis and decreased growth of PIK3CA-mutant tumors (AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 156).

DrugClasses PIK3CA inhibitor 21
CAS Registry Number 2060571-02-8
NCIT ID C132166


  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")


  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Ado-trastuzumab emtansine + GDC-0077 Ado-trastuzumab emtansine GDC-0077 0 0
Bevacizumab + GDC-0077 Bevacizumab GDC-0077 0 1
Capecitabine + GDC-0077 Capecitabine GDC-0077 0 1
Cetuximab + GDC-0077 Cetuximab GDC-0077 0 1
Fulvestrant + GDC-0077 Fulvestrant GDC-0077 0 2
Fulvestrant + GDC-0077 + Palbociclib Fulvestrant GDC-0077 Palbociclib 0 1
GDC-0077 GDC-0077 8 4
GDC-0077 + Giredestrant GDC-0077 Giredestrant 0 1
GDC-0077 + Lapatinib GDC-0077 Lapatinib 0 0
GDC-0077 + Letrozole GDC-0077 Letrozole 0 1
GDC-0077 + Letrozole + Palbociclib GDC-0077 Letrozole Palbociclib 0 1
GDC-0077 + Pertuzumab + Trastuzumab GDC-0077 Pertuzumab Trastuzumab 0 0
GDC-0077 + Pertuzumab/trastuzumab/hyaluronidase-zzxf GDC-0077 Pertuzumab/trastuzumab/hyaluronidase-zzxf 0 1
GDC-0077 + Pertuzumab/trastuzumab/hyaluronidase-zzxf + Tamoxifen GDC-0077 Pertuzumab/trastuzumab/hyaluronidase-zzxf Tamoxifen 0 1

Additional content available in CKB BOOST