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Drug Name TTI-621
Trade Name
Synonyms SIRPalpha-Fc|TTI621|TTI 621|Ontorpacept
Drug Descriptions

TTI-621 (Ontorpacept) is a fusion, consisting of SIRPa fused to the human IgG1 Fc region, that binds to CD47 and blocks inhibitory signaling to macrophages, resulting in increased phagocytosis of tumor cells (PMID: 27856600, PMID: 28286286) may also stimulate cytotoxic T-cells (PMID: 29873856).

DrugClasses CD47 Antibody 18 Immune Checkpoint Inhibitor 141
CAS Registry Number 2131089-46-6
NCIT ID C125718

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Daratumumab + TTI-621 Daratumumab TTI-621 0 1
Doxorubicin + TTI-621 Doxorubicin TTI-621 0 1
TTI-621 TTI-621 0 2


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