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Drug Name Preladenant
Trade Name
Synonyms MK-3814|SCH420814
Drug Descriptions

Preladenant (MK-3814) binds to and inhibits the adenosine A2A (ADORA2A) receptor on immune cells, resulting in activation of an anti-tumor immune response by blocking binding of the immunosuppressive metabolite, adenosine (PMID: 22676397, PMID: 19109019).

DrugClasses Adenosine Targeting 23
CAS Registry Number 377727-87-2
NCIT ID C76394

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Pembrolizumab + Preladenant Pembrolizumab Preladenant 0 1
Preladenant Preladenant 0 1


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