Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : ckbsupport@jax.org
Drug Name | APG-115 |
Trade Name | |
Synonyms | APG115|APG 115|Alrizomadlin |
Drug Descriptions |
APG-115, a derivative of SAR405838, inhibits MDM2 and its interaction with p53, thereby stabilizing and activating wild-type p53, which may result in antitumor activity and also synergizes with PD-1 inhibitors (PMID: 28498808, PMID: 31779710). |
DrugClasses | MDM2 Inhibitor 20 |
CAS Registry Number | 1818393-16-6 |
NCIT ID | C132991 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
APG-115 | APG-115 | 1 | 4 |
APG-115 + APG-2575 | APG-115 APG-2575 | 0 | 1 |
APG-115 + Azacitidine | APG-115 Azacitidine | 0 | 1 |
APG-115 + Carboplatin | APG-115 Carboplatin | 0 | 0 |
APG-115 + Pembrolizumab | APG-115 Pembrolizumab | 0 | 1 |