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Drug Name APG-115
Trade Name
Synonyms APG115|APG 115|Alrizomadlin
Drug Descriptions

APG-115, a derivative of SAR405838, inhibits MDM2 and its interaction with p53, thereby stabilizing and activating wild-type p53, which may result in antitumor activity and also synergizes with PD-1 inhibitors (PMID: 28498808, PMID: 31779710).

DrugClasses MDM2 Inhibitor 20
CAS Registry Number 1818393-16-6
NCIT ID C132991

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Therapy Name Drugs Efficacy Evidence Clinical Trials
APG-115 APG-115 1 4
APG-115 + APG-2575 APG-115 APG-2575 0 1
APG-115 + Azacitidine APG-115 Azacitidine 0 1
APG-115 + Carboplatin APG-115 Carboplatin 0 1
APG-115 + Pembrolizumab APG-115 Pembrolizumab 0 0


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