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Drug Name JCAR017
Trade Name
Synonyms Lisocabtagene maraleucel|JCAR 017
Drug Descriptions

JCAR017 (lisocabtagene maraleucel) comprises equal amount of CD4+ and CD8+ autologous T lymphocytes engineered to express chimeric antigen receptors containing an anti-CD19 fragment fused to the 4-1BB (CD137) signaling domain, which may results in immune modulating and anti-tumor activities (J Clin Oncol 35, 2017 (suppl; abstr 7513)).

DrugClasses

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cyclophosphamide + Fludarabine + JCAR017 Cyclophosphamide Fludarabine JCAR017 0 1
Durvalumab + JCAR017 Durvalumab JCAR017 0 1
Ibrutinib + JCAR017 Ibrutinib JCAR017 0 1
JCAR017 JCAR017 2 4


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