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Drug Name Lisocabtagene maraleucel
Trade Name Breyanzi
Synonyms JCAR 017|JCAR017|JCAR-017
Drug Descriptions

Breyanzi (lisocabtagene maraleucel) comprises equal amount of CD4+ and CD8+ autologous T lymphocytes engineered to express chimeric antigen receptors containing an anti-CD19 fragment fused to the 4-1BB (CD137) signaling domain, which may results in immune modulating and anti-tumor activities (PMID: 32888407). Breyanzi (lisocabtagene maraleucel) is FDA approved for use in patients with relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy, including diffuse large B-cell lymphoma, high-grade B-cell lymphoma, primary mediastinal large B-cell lymphoma, and follicular lymphoma grade 3B (FDA.gov).

CAS Registry Number NA
NCIT ID C125192


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cyclophosphamide + Fludarabine + Lisocabtagene maraleucel Cyclophosphamide Fludarabine Lisocabtagene maraleucel 0 2
Durvalumab + Lisocabtagene maraleucel Durvalumab Lisocabtagene maraleucel 0 1
Ibrutinib + Lisocabtagene maraleucel Ibrutinib Lisocabtagene maraleucel 0 1
Lisocabtagene maraleucel Lisocabtagene maraleucel 0 6

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