Drug Detail


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Drug Name LY2603618
Trade Name
Synonyms LY-2603618|Rabusertib
Drug Descriptions

Rabusertib (LY2603618) is a small molecule that inhibits CHK1, which may lead to disruption of DNA synthesis, early mitosis, and apoptosis, and may increase tumor cell sensitivity to chemotherapeutics (PMID: 24114124, PMID: 28625637).

DrugClasses CHK1 Inhibitor 15
CAS Registry Number 911222-45-2
NCIT ID C81937


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cisplatin + LY2603618 + Pemetrexed Disodium Cisplatin LY2603618 Pemetrexed Disodium 0 0
Gemcitabine + LY2603618 Gemcitabine LY2603618 0 0
LB-100 + LY2603618 LB-100 LY2603618 0 0
LY2603618 LY2603618 0 0
LY2603618 + Pemetrexed Disodium LY2603618 Pemetrexed Disodium 0 0

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