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Drug Name CPI-613
Trade Name
Synonyms CPI613|CPI 613|Devimistat
Drug Descriptions

Devimistat (CPI-613) is an inhibitor of pyruvate dehydrogenase (PDH) and alpha-ketogluterate (KGDH), resulting in blockade of mitochondrial respiration which may lead to apoptosis and death of cancer cells (PMID: 29437791, PMID: 28495639, PMID: 32789692, PMID: 31512500).

CAS Registry Number 95809-78-2
NCIT ID C80039


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bendamustine + CPI-613 Bendamustine CPI-613 0 1
Cisplatin + CPI-613 + Gemcitabine CPI-613 Cisplatin Gemcitabine 0 1
CPI-613 CPI-613 0 2
CPI-613 + Cytarabine + Mitoxantrone CPI-613 Cytarabine Mitoxantrone 0 1
CPI-613 + Fluorouracil + Hydroxychloroquine CPI-613 Fluorouracil Hydroxychloroquine 0 1
CPI-613 + Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin CPI-613 Fluorouracil Irinotecan Leucovorin Oxaliplatin 0 4
CPI-613 + Gemcitabine CPI-613 Gemcitabine 0 1
CPI-613 + Gemcitabine + Hydroxychloroquine CPI-613 Gemcitabine Hydroxychloroquine 0 1
CPI-613 + Hydroxychloroquine CPI-613 Hydroxychloroquine 0 3
CPI-613 + Metformin CPI-613 Metformin 0 1

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