Drug Detail


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Drug Name RAF709
Trade Name
Synonyms RAF-709
Drug Descriptions

RAF709 is an ATP-competitive inhibitor that inhibits both BRAF monomers and RAF dimers, resulting in growth inhibition in tumor cells (PMID: 29343524).

DrugClasses BRAF Inhibitor 25 CRAF Inhibitor 12
CAS Registry Number 1628838-42-5


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Binimetinib + RAF709 Binimetinib RAF709 3 0
Dabrafenib + RAF709 + Trametinib Dabrafenib RAF709 Trametinib 2 0
Osimertinib + RAF709 Osimertinib RAF709 0 0
Osimertinib + RAF709 + SCH772984 Osimertinib RAF709 SCH772984 0 0
Osimertinib + RAF709 + Trametinib Osimertinib RAF709 Trametinib 0 0
RAF709 RAF709 7 0
RAF709 + Selumetinib RAF709 Selumetinib 0 0
RAF709 + Trametinib RAF709 Trametinib 0 0

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