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CC-90002 is monoclonal antibody against CD47 that binds to and blocks CD47 downstream signaling and subsequent activation of the SIRPa receptor on macrophages, leading to phagocytosis of tumor cells (PMID: 28286286) and may also stimulate cytotoxic T-cells (PMID: 29873856).
|DrugClasses||CD47 Antibody 13 Immune Checkpoint Inhibitor 94|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|CC-90002 + Rituximab||CC-90002 Rituximab||0||1|