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Drug Name Effi-DEM
Trade Name
Synonyms OSE-172|BI 765063|BI-765063|OSE 172
Drug Descriptions

Effi-DEM (OSE-172) is a monoclonal antibody to the SIRPa receptor that blocks the CD47-SIRPa interaction to promote macrophage phagocytosis of tumor cells and may stimulate cytotoxic T-cells (PMID: 29873856).

DrugClasses Immune Checkpoint Inhibitor 148
CAS Registry Number NA
NCIT ID C179278

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Therapy Name Drugs Efficacy Evidence Clinical Trials
BI 836880 + Effi-DEM + Ezabenlimab BI 836880 Effi-DEM Ezabenlimab 0 1
Cetuximab + Effi-DEM + Ezabenlimab Cetuximab Effi-DEM Ezabenlimab 0 1
Effi-DEM Effi-DEM 0 1
Effi-DEM + Ezabenlimab Effi-DEM Ezabenlimab 0 2


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