Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Effi-DEM
Trade Name
Synonyms OSE-172|BI 765063|BI-765063|OSE 172|BI765063
Drug Descriptions

Effi-DEM (OSE-172) is a monoclonal antibody to the SIRPa receptor that blocks the CD47-SIRPa interaction to promote macrophage phagocytosis of tumor cells and may stimulate cytotoxic T-cells (PMID: 29873856).

DrugClasses Immune Checkpoint Inhibitor 155
CAS Registry Number NA
NCIT ID C179278


  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")


  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
BI 836880 + Effi-DEM + Ezabenlimab BI 836880 Effi-DEM Ezabenlimab 0 1
Cetuximab + Effi-DEM + Ezabenlimab Cetuximab Effi-DEM Ezabenlimab 0 1
Effi-DEM Effi-DEM 0 1
Effi-DEM + Ezabenlimab Effi-DEM Ezabenlimab 0 3
Effi-DEM + Pembrolizumab Effi-DEM Pembrolizumab 0 1

Additional content available in CKB BOOST