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GSK3145095 is a small molecule that inhibits RIPK1, resulting in decreased downstream signaling, and potentially leading to reduced recruitment of immunosuppressive cells in the tumor microenvironment and increased tumor cell death (PMID: 31223438).
|CAS Registry Number||1622849-43-7|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|GSK3145095 + Pembrolizumab||GSK3145095 Pembrolizumab||0||1|