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Drug Name IBI188
Trade Name
Synonyms IBI-188|IBI 188|letaplimab
Drug Descriptions

IBI188 (letaplimab) is an antibody against CD47 that binds to and blocks CD47 downstream signaling and subsequent activation of the SIRPa receptor on macrophages, potentially leading to phagocytosis of tumor cells, activation of cytotoxic T-cells (Blood (2022) 140 (Supplement 1): 4045-4046, NCI Drug Dictionary).

DrugClasses CD47 Antibody 30
CAS Registry Number 2283356-07-8
NCIT ID C157385

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Azacitidine + IBI188 Azacitidine IBI188 0 0
IBI188 IBI188 0 1


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