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Drug Name RMC-4630
Trade Name
Synonyms RMC-4630-02|SAR442720|SAR 442720
Drug Descriptions

RMC-4630 is an inhibitor of SHP2 (PTPN11) that prevents MAPK signaling and cell growth (PMID: 31727671).

DrugClasses SHP2 Inhibitor 20
CAS Registry Number NA
NCIT ID C155850

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Adagrasib + RMC-4630 Adagrasib RMC-4630 0 1
Cobimetinib + RMC-4630 Cobimetinib RMC-4630 0 1
LY3214996 + RMC-4630 LY3214996 RMC-4630 0 1
Osimertinib + RMC-4630 Osimertinib RMC-4630 0 1
Pembrolizumab + RMC-4630 Pembrolizumab RMC-4630 0 1
RMC-4630 RMC-4630 0 1
RMC-4630 + Sotorasib RMC-4630 Sotorasib 0 2


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