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Drug Name TPST-1120
Trade Name
Synonyms TPST1120|TPST 1120
Drug Descriptions

TPST-1120 is a peroxisome proliferator-activated receptor alpha (PPARa) antagonist, which inhibits transcription of PPAR alpha genes to alter fatty acid metabolism thereby inducing macrophages to an M1 phenotype for increased cytotoxicity (Journal of Clinical Oncology 37, no. 15_suppl., TPS2665).

DrugClasses
CAS Registry Number NA
NCIT ID C169105

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + Bevacizumab + TPST-1120 Atezolizumab Bevacizumab TPST-1120 0 0
Cetuximab + TPST-1120 Cetuximab TPST-1120 0 1
Docetaxel + TPST-1120 Docetaxel TPST-1120 0 1
Nivolumab + TPST-1120 Nivolumab TPST-1120 0 1
TPST-1120 TPST-1120 0 1


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