Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name TPST-1120
Trade Name
Synonyms TPST1120|TPST 1120
Drug Descriptions

TPST-1120 is a peroxisome proliferator-activated receptor alpha (PPARa) antagonist, which inhibits transcription of PPAR alpha genes to alter fatty acid metabolism thereby inducing macrophages to an M1 phenotype for increased cytotoxicity (Journal of Clinical Oncology 37, no. 15_suppl., TPS2665).

CAS Registry Number NA
NCIT ID C169105


  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")


  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + Bevacizumab + TPST-1120 Atezolizumab Bevacizumab TPST-1120 0 0
Cetuximab + TPST-1120 Cetuximab TPST-1120 0 1
Docetaxel + TPST-1120 Docetaxel TPST-1120 0 1
Nivolumab + TPST-1120 Nivolumab TPST-1120 0 1
TPST-1120 TPST-1120 0 1

Additional content available in CKB BOOST