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Drug Name NOX-A12
Trade Name
Synonyms Olaptesed Pegol|NOX A12|NOXA12
Drug Descriptions

NOX-A12 (olaptesed pegol) binds to CXCL12 and inhibits its interaction with CXCR4 and CXCR7, potentially resulting in increased sensitivity to chemotherapeutic agents, as well as increased infiltration of T-cells into tumors and enhanced anti-tumor immune response in combination with other agents (PMID: 24277076, PMID: 28963140).

CAS Registry Number 1390628-22-4
NCIT ID C99379


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bendamustine + NOX-A12 + Rituximab Bendamustine NOX-A12 Rituximab 0 0
Bevacizumab + NOX-A12 Bevacizumab NOX-A12 0 1
Nilotinib + NOX-A12 NOX-A12 Nilotinib 0 0
NOX-A12 NOX-A12 0 1
NOX-A12 + Pembrolizumab NOX-A12 Pembrolizumab 0 0
NOX-A12 + unspecified PD-1 antibody NOX-A12 unspecified PD-1 antibody 0 0

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