Drug Detail


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Drug Name Vepdegestrant
Trade Name
Synonyms ARV471|ARV 471|PF 07850327|PF07850327|PF-07850327|ARV-471
Drug Descriptions

Vepdegestrant (ARV-471) is a bifunctional molecule that targets the estrogen receptor (ESR1), including ESR1 variants, for proteolytic degradation resulting in reduced target gene expression and potentially leading to reduced cell proliferation and inhibition of tumor growth (Cancer Res 2019;79(4 Suppl):Abstract nr P5-04-18, PMID: 32829249).

DrugClasses Hormone - Anti-estrogens 25
CAS Registry Number 2229711-68-4
NCIT ID C165420


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Vepdegestrant Abemaciclib Vepdegestrant 0 1
Everolimus + Vepdegestrant Everolimus Vepdegestrant 0 1
Letrozole + Vepdegestrant Letrozole Vepdegestrant 0 0
Palbociclib + Vepdegestrant Palbociclib Vepdegestrant 0 2
Ribociclib + Vepdegestrant Ribociclib Vepdegestrant 0 1
Samuraciclib + Vepdegestrant Samuraciclib Vepdegestrant 0 1
Vepdegestrant Vepdegestrant 0 3

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