Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@jax.org
Drug Name | Vepdegestrant |
Trade Name | |
Synonyms | ARV471|ARV 471|PF 07850327|PF07850327|PF-07850327|ARV-471 |
Drug Descriptions |
Vepdegestrant (ARV-471) is a bifunctional molecule that targets the estrogen receptor (ESR1), including ESR1 variants, for proteolytic degradation resulting in reduced target gene expression and potentially leading to reduced cell proliferation and inhibition of tumor growth (Cancer Res 2019;79(4 Suppl):Abstract nr P5-04-18, PMID: 32829249). |
DrugClasses | Hormone - Anti-estrogens 25 |
CAS Registry Number | 2229711-68-4 |
NCIT ID | C165420 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Abemaciclib + Vepdegestrant | Abemaciclib Vepdegestrant | 0 | 1 |
Everolimus + Vepdegestrant | Everolimus Vepdegestrant | 0 | 1 |
Letrozole + Vepdegestrant | Letrozole Vepdegestrant | 0 | 0 |
Palbociclib + Vepdegestrant | Palbociclib Vepdegestrant | 0 | 2 |
Ribociclib + Vepdegestrant | Ribociclib Vepdegestrant | 0 | 1 |
Samuraciclib + Vepdegestrant | Samuraciclib Vepdegestrant | 0 | 1 |
Vepdegestrant | Vepdegestrant | 0 | 3 |