Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Vepdegestrant
Trade Name
Synonyms ARV471|ARV 471|PF 07850327|PF07850327|PF-07850327|ARV-471
Drug Descriptions

Vepdegestrant (ARV-471) is a bifunctional molecule that targets the estrogen receptor (ESR1), including ESR1 variants, for proteolytic degradation resulting in reduced target gene expression and potentially leading to reduced cell proliferation and inhibition of tumor growth (Cancer Res 2019;79(4 Suppl):Abstract nr P5-04-18, PMID: 32829249).

DrugClasses Hormone - Anti-estrogens 25
CAS Registry Number 2229711-68-4
NCIT ID C165420

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Vepdegestrant Abemaciclib Vepdegestrant 0 1
Everolimus + Vepdegestrant Everolimus Vepdegestrant 0 1
Letrozole + Vepdegestrant Letrozole Vepdegestrant 0 0
Palbociclib + Vepdegestrant Palbociclib Vepdegestrant 0 2
PF-07220060 + Vepdegestrant PF-07220060 Vepdegestrant 0 1
Ribociclib + Vepdegestrant Ribociclib Vepdegestrant 0 1
Samuraciclib + Vepdegestrant Samuraciclib Vepdegestrant 0 1
Vepdegestrant Vepdegestrant 0 3


Additional content available in CKB BOOST