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AOH1160 is a small molecule inhibitor that specifically targets cancer associated PCNA (caPCNA) and binds to the region between L126 and Y133, thereby interfering with elongation of the replication fork, and subsequently leading to cell cycle arrest, apoptosis, and tumor growth inhibition (PMID: 29967249).
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|AOH1160 + Cisplatin||AOH1160 Cisplatin||0||0|