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AsiDNA is an oligodeoxyribonucleotide drug that acts as a DNA repair pathway antagonist by mimicking double-stranded DNA breaks and subsequently recruiting DNA repair proteins, thereby preventing the repair of other DNA damaged sites, and thus, potentially leading to increased cell death and inhibition of cell proliferation (PMID: 27559053, PMID: 32839491).
|CAS Registry Number||NA|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|AsiDNA + AZD2461||AZD2461 AsiDNA||1||0|
|AsiDNA + Iniparib||AsiDNA Iniparib||1||0|
|AsiDNA + Niraparib||AsiDNA Niraparib||1||0|
|AsiDNA + Olaparib||AsiDNA Olaparib||7||0|
|AsiDNA + Rucaparib||AsiDNA Rucaparib||1||0|
|AsiDNA + Talazoparib||AsiDNA Talazoparib||1||0|
|AsiDNA + Veliparib||AsiDNA Veliparib||1||0|