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Drug Name HuJCAR014
Trade Name
Synonyms Anti-CD19-CAR Genetically Engineered Autologous T-lymphocytes huJCAR014
Drug Descriptions

HuJCAR014 comprises CD4+ and CD8+ autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) that consists of an anti-CD19 fragment linked to the 4-1BB (CD137) signaling domain and truncated human epidermal growth factor receptor, which has potential cytotoxic activity against CD19-expressing tumor cells (NCI Drug Dictionary).

DrugClasses CD19 Antibody 15
CAS Registry Number NA
NCIT ID C133191


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cyclophosphamide + Fludarabine + HuJCAR014 Cyclophosphamide Fludarabine HuJCAR014 0 1
HuJCAR014 HuJCAR014 0 0

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