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|Synonyms||Anti-CD19-CAR Genetically Engineered Autologous T-lymphocytes huJCAR014|
HuJCAR014 comprises CD4+ and CD8+ autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) that consists of an anti-CD19 fragment linked to the 4-1BB (CD137) signaling domain and truncated human epidermal growth factor receptor, which has potential cytotoxic activity against CD19-expressing tumor cells (NCI Drug Dictionary).
|DrugClasses||CD19 Antibody 9|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|Cyclophosphamide + Fludarabine + HuJCAR014||Cyclophosphamide Fludarabine HuJCAR014||0||1|