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Drug Name CC-99282
Trade Name
Synonyms CC99282|CC 99282|BMS-986369|BMS986369|BMS 986369|Golcadomide
Drug Descriptions

CC-99282 modulates cereblon E3 ubiquitin ligase, leading to degradation of the transcription factors Ikaros and Aiolos, potentially resulting in decreased tumor cell proliferation, enhanced apoptosis, and antitumor activity (Blood (2021) 138 (Supplement 1).

DrugClasses
CAS Registry Number 953769-46-5
NCIT ID C172396

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Therapy Name Drugs Efficacy Evidence Clinical Trials
CC-99282 CC-99282 0 2
CC-99282 + Cyclophosphamide + Doxorubicin + Prednisone + Rituximab + Vincristine Sulfate CC-99282 Cyclophosphamide Doxorubicin Prednisone Rituximab Vincristine Sulfate 0 2
CC-99282 + Glofitamab-gxbm CC-99282 Glofitamab-gxbm 0 1
CC-99282 + Mosunetuzumab-axgb CC-99282 Mosunetuzumab-axgb 0 1
CC-99282 + Nivolumab + Rituximab CC-99282 Nivolumab Rituximab 0 1
CC-99282 + Obinutuzumab CC-99282 Obinutuzumab 0 2
CC-99282 + Rituximab CC-99282 Rituximab 0 4


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