Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name DT2216
Trade Name
Synonyms DT 2216|DT-2216|PROTAC Bcl-XL Deagrader DT2216
Drug Descriptions

DT2216 is a small molecule proteolysis-targeted chimera (PROTAC) that binds to BCL-XL and targets it for degradation, potentially resulting in decreased tumor growth (PMID: 31792461, PMID: 32677976).

DrugClasses BCL-XL inhibitor 14
CAS Registry Number NA
NCIT ID C179922

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Asparaginase + Dexamethasone + DT2216 + Vincristine Sulfate Asparaginase DT2216 Dexamethasone Vincristine Sulfate 0 0
Docetaxel + DT2216 DT2216 Docetaxel 0 0
Doxorubicin + DT2216 DT2216 Doxorubicin 0 0
DT2216 DT2216 0 1
DT2216 + S63845 DT2216 S63845 0 0
DT2216 + Sotorasib DT2216 Sotorasib 0 0
DT2216 + Venetoclax DT2216 Venetoclax 0 0
DT2216 + Vincristine Sulfate DT2216 Vincristine Sulfate 0 0


Additional content available in CKB BOOST