Drug Detail


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Drug Name DT2216
Trade Name
Synonyms DT 2216|DT-2216|PROTAC Bcl-XL Deagrader DT2216
Drug Descriptions

DT2216 is a small molecule proteolysis-targeted chimera (PROTAC) that binds to BCL-XL and targets it for degradation, potentially resulting in decreased tumor growth (PMID: 31792461, PMID: 32677976).

DrugClasses BCL-XL inhibitor 14
CAS Registry Number NA
NCIT ID C179922


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Asparaginase + Dexamethasone + DT2216 + Vincristine Sulfate Asparaginase DT2216 Dexamethasone Vincristine Sulfate 0 0
Docetaxel + DT2216 DT2216 Docetaxel 0 0
Doxorubicin + DT2216 DT2216 Doxorubicin 0 0
DT2216 DT2216 0 1
DT2216 + S63845 DT2216 S63845 0 0
DT2216 + Sotorasib DT2216 Sotorasib 0 0
DT2216 + Venetoclax DT2216 Venetoclax 0 0
DT2216 + Vincristine Sulfate DT2216 Vincristine Sulfate 0 0

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