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Drug Name Pirtobrutinib
Trade Name Jaypirca
Synonyms LOXO-305|LOXO 305|LOXO305|RXC005|REDX08608
Drug Descriptions

Jaypirca (pirtobrutinib) selectively inhibits the activation of BTK, which may result in decreased tumor growth (PMID: 32170458, PMID: 33676628). Jaypirca (pirtobrutinib) is FDA approved for use in patients with relapsed or refractory mantle cell lymphoma who had received at least two lines of systemic therapy, and in patients with chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) who have received at least two prior lines of therapy (FDA.gov).

DrugClasses BTK inhibitor 36
CAS Registry Number 2101700-15-4
NCIT ID C158617

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cyclophosphamide + Doxorubicin + Pirtobrutinib + Prednisone + Rituximab + Vincristine Sulfate Cyclophosphamide Doxorubicin Pirtobrutinib Prednisone Rituximab Vincristine Sulfate 0 1
Glofitamab-gxbm + Obinutuzumab + Pirtobrutinib Glofitamab-gxbm Obinutuzumab Pirtobrutinib 0 1
Glofitamab-gxbm + Pirtobrutinib Glofitamab-gxbm Pirtobrutinib 0 1
LOXO-338 + Pirtobrutinib LOXO-338 Pirtobrutinib 0 1
Obinutuzumab + Pirtobrutinib Obinutuzumab Pirtobrutinib 0 1
Obinutuzumab + Pirtobrutinib + Venetoclax Obinutuzumab Pirtobrutinib Venetoclax 0 1
Pirtobrutinib Pirtobrutinib 2 7
Pirtobrutinib + Rituximab Pirtobrutinib Rituximab 0 2
Pirtobrutinib + Rituximab + Venetoclax Pirtobrutinib Rituximab Venetoclax 0 2
Pirtobrutinib + Venetoclax Pirtobrutinib Venetoclax 0 6


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