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Drug Name Tinengotinib
Trade Name
Synonyms TT00420|TT 00420|TT-00420
Drug Descriptions

Tinengotinib (TT-00420) is a multikinase inhibitor that targets AURKA, AURKB, FGFR1-3, VEGFR, JAK1/2, and CSF1R, potentially resulting in decreased cell proliferation and inhibition of tumor growth (PMID: 36223547).

DrugClasses Aurka Inhibitors 27 Aurkb Inhibitors 21 CSF1R Inhibitor 28 FGFR1 Inhibitor 28 FGFR2 Inhibitor 23 FGFR3 Inhibitor 19 JAK Inhibitor (Pan) 9 VEGFR Inhibitor (Pan) 36
CAS Registry Number 2230490-29-4
NCIT ID C162532

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abiraterone + Enzalutamide + Tinengotinib Abiraterone Enzalutamide Tinengotinib 0 1
Abiraterone + Prednisone + Tinengotinib Abiraterone Prednisone Tinengotinib 0 1
Enzalutamide + Tinengotinib Enzalutamide Tinengotinib 0 0
Nab-paclitaxel + Tinengotinib Nab-paclitaxel Tinengotinib 0 1
Tinengotinib Tinengotinib 4 4


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