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Drug Name CC-92480
Trade Name
Synonyms CELMoD CC92480|CC 92480
Drug Descriptions

CC-92480 binds to and modulates activity of the ubiquitin E3 ligase complex member Cereblon (CRBN), which may induce ubiquitination and degradation of transcription factors in T-lymphocytes, resulting in immune system activation (Blood (2019) 134 (Supplement_1): 1812, PMID: 32130004).

DrugClasses

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bortezomib + CC-92480 + Dexamethasone Bortezomib CC-92480 Dexamethasone 0 1
Carfilzomib + CC-92480 + Dexamethasone CC-92480 Carfilzomib Dexamethasone 0 1
CC-92480 CC-92480 1 0
CC-92480 + Daratumumab + Dexamethasone CC-92480 Daratumumab Dexamethasone 0 1
CC-92480 + Dexamethasone CC-92480 Dexamethasone 1 1


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