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Drug Name CC-92480
Trade Name
Synonyms CELMoD CC92480|CC 92480|Mezigdomide|BMS-986348|BMS986348|BMS 986348
Drug Descriptions

CC-92480 binds to and modulates activity of the ubiquitin E3 ligase complex member Cereblon (CRBN), which may induce ubiquitination and degradation of transcription factors in T-lymphocytes, resulting in immune system activation (Blood (2019) 134 (Supplement_1): 1812, PMID: 32130004).

CAS Registry Number 2259648-80-9
NCIT ID C146660


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Therapy Name Drugs Efficacy Evidence Clinical Trials
BMS-986393 + CC-92480 BMS-986393 CC-92480 0 1
BMS986158 + CC-92480 + Dexamethasone BMS986158 CC-92480 Dexamethasone 0 1
Bortezomib + CC-92480 + Dexamethasone Bortezomib CC-92480 Dexamethasone 0 2
Carfilzomib + CC-92480 + Dexamethasone CC-92480 Carfilzomib Dexamethasone 0 2
CC-92480 CC-92480 0 1
CC-92480 + CC-93269 + Dexamethasone CC-92480 CC-93269 Dexamethasone 0 1
CC-92480 + Daratumumab + Dexamethasone CC-92480 Daratumumab Dexamethasone 0 1
CC-92480 + Dexamethasone CC-92480 Dexamethasone 0 2
CC-92480 + Dexamethasone + Elotuzumab CC-92480 Dexamethasone Elotuzumab 0 1
CC-92480 + Dexamethasone + Ixazomib CC-92480 Dexamethasone Ixazomib 0 1
CC-92480 + Dexamethasone + Tazemetostat CC-92480 Dexamethasone Tazemetostat 0 1
CC-92480 + Dexamethasone + Trametinib CC-92480 Dexamethasone Trametinib 0 1

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