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Drug Name ONCR-177
Trade Name
Synonyms ONCR177|ONCR 177
Drug Descriptions

ONCR-177 is an oncolytic herpes simplex virus (HSV) engineered to express PD-1 and CTLA-4 antagonists, IL-12, CCL4, and the extracellular domain of FLT3LG, and to contain a microRNA-binding cassette that potentially allows selective HSV replication in tumor cells, which may enhance anti-tumor immune response and induce tumor cell killing (Cancer Res 2019;79(13 Suppl):Abstract nr 1455).

DrugClasses CTLA4 Inhibitor 3
CAS Registry Number NA
NCIT ID C171540


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Therapy Name Drugs Efficacy Evidence Clinical Trials
ONCR-177 ONCR-177 0 1
ONCR-177 + Pembrolizumab ONCR-177 Pembrolizumab 0 1

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